reported that the detection rate is about 60% in Taiwan. Double (AFP and hCG) and triple (plus uE3) serum screening have been implemented in Taiwan since 1994 and have been liberally used thereafter. Triple screening builds on the maternal age-specific a priori risk for DS and refines it using three serum markers. introduced triple screening, which examines maternal serum alpha-fetoprotein (MSAFP), estriol (E3), and human chorionic gonadotropin (hCG). The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.ĭown Syndrome (DS) is one of the most common causes of mental retardation and congenital abnormalities. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.
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